The Role of Ginger in Cognitive and Antidepressant Function: A Preliminary Exploration of the Effect of Added Sugars

Jennifer Mariza Lynn, Budi Widianarko, Mellia Harumi

Abstract


Ginger offers antioxidant, anti-inflammatory, and neuroprotective properties that can enhance cognitive function and act as an antidepressant. However, excessive sugar intake has been linked to cognitive decline and mental health issues. This review explores the role of added sugar on ginger's ability to improve cognitive function and be an antidepressant. This review is a narrative review that utilizes data collected from various sources of relevant scientific literature spanning from 2014 to 2024. The literature search used online databases and search engines with predetermined keywords. Relevant articles were then selected in two stages. The first selection stage was done by looking at the article's suitability based on the title, keywords, and abstract. The second stage was conducted based on predetermined inclusion and exclusion criteria. The research design includes a comprehensive analysis of the role of ginger and sugar and their combination in cognitive function and antidepressant effects. The findings indicate that many sweet ginger products contain high sugar levels, which can reduce ginger’s antioxidant effectiveness and increase oxidative stress. Furthermore, sugar may raise inflammation and amyloid-beta levels, potentially increasing Alzheimer's risk. In conclusion, while ginger holds significant promise for enhancing cognitive function and mood, the adverse effects of added sugar may negate these benefits.


Keywords


Antidepressant; Cognitive Function; Ginger; Sugar

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References


Akib, N. I., Baane, W., & Fristiohady, A. (2016). Formulation of Herbal Hard Candy Contains Red Ginger (Zingiber officinale var. rubrum) Extract. Jf Fik Uinam, 4(1), 1–8.

AlAmmar, W. A., Albeesh, F. H., & Khattab, R. Y. (2020). Food and Mood: the Corresponsive Effect. Current Nutrition Reports, 9(3), 296–308. https://doi.org/10.1007/s13668-020-00331-3

Albeha, M., Fernandes, S., Mesquita, D., Seabra, F., & Ferreira-Oliveira, A. (2020). La empleabilidad de los graduados y el desarrollo de competencias en la educación superior: una revisión sistemática de la literatura utilizando PRISMA. Sustainability, 12(15), 1–27. https://www-scopus-com.unmsm.lookproxy.com/record/display.uri?eid=2-s2.0-85089738422&origin=resultslist&sort=plf-f&src=s&nlo=&nlr=&nls=&sid=45029e5b6145459ddd4bee918b9d0e30&sot=a&sdt=cl&cluster=scoexactsrctitle%2C%22Revesco+Revista+De+Estudios+Cooperativo

Amalia, S. R., Rostini, I., Syamsuddin, M. L., & Pratama, R. I. (2021). Chemical and Organoleptic Characteristics of Seaweed Jelly Candy (Eucheuma cottonii) with the Addition of Red Ginger (Zingiber officinale Roscoe) Extract. Asian Journal of Fisheries and Aquatic Research, June, 33–43. https://doi.org/10.9734/ajfar/2021/v12i530246

Andina Mayangsari, Angga Kurdiansyah, & Moch Imam Vickry Musthofa. (2024). Sosialisasi Dan Praktek Pemberdayaan Masyarakat Dalam Pembuatan Sirup Jahe Pada Dasawiswa Melati Sumberanyar Banyuputih Situbondo. Jurnal Kabar Masyarakat, 2(2), 264–269. https://doi.org/10.54066/jkb.v2i2.1973

Arcusa, R., Villaño, D., Marhuenda, J., Cano, M., Cerdà, B., & Zafrilla, P. (2022). Potential Role of Ginger (Zingiber officinale Roscoe) in Preventing Neurodegenerative Diseases. Frontiers in Nutrition, 9(March). https://doi.org/10.3389/fnut.2022.809621

Ayustaningwarno, F., Anjani, G., Ayu, A. M., & Fogliano, V. (2024). A critical review of Ginger’s (Zingiber officinale) antioxidant, anti-inflammatory, and immunomodulatory activities. Frontiers in Nutrition, 11(June), 1–16. https://doi.org/10.3389/fnut.2024.1364836

Azam, F., Amer, A. M., Abulifa, A. R., & Elzwawi, M. M. (2014). Ginger components as new leads for the design and development of novel multi-targeted anti-Alzheimer’s drugs: A computational investigation. Drug design, development and therapy, 2045-2059.

Badan POM. (2020). Pedoman untuk UMKM dalam pengolahan jahe. https://istanaumkm.pom.go.id/download/1015

Badrunanto, Wahyuni, W. T., Farid, M., Batubara, I., & Yamauchi, K. (2024). Antioxidant components of the three different varieties of Indonesian ginger essential oil: In vitro and computational studies. Food Chemistry Advances, 4(November 2023), 100558. https://doi.org/10.1016/j.focha.2023.100558

Bano, S., Sharif, H., & Badawy, A. A.-B. (2021). Effects of oral administration of an aqueous ginger extract on anxiety behavior and tryptophan and serotonin metabolism in the rat. Asian Journal of Medical Sciences, 12(6), 38–43. https://doi.org/10.3126/ajms.v12i6.34480

Beilharz, J. E., Maniam, J., & Morris, M. J. (2015). Diet-induced cognitive deficits: The role of fat and sugar, potential mechanisms and nutritional interventions. Nutrients, 7(8), 6719–6738. https://doi.org/10.3390/nu7085307

Dania, I. A., Rusdiana, Rambe, A. S., Harahap, U., Effendy, E., & Novziransyah, N. (2024). Active Compounds of Red Ginger as Antioxidant Activity in the Supplementation and Treatment of Depression. Qubahan Academic Journal, 4(1), 177–184. https://doi.org/10.48161/qaj.v4n1a208

Diyana, I., Kamaluddin, K., Nawawi, N. M., Syamsu, R. F., Royani, I., & Haidir Bima, I. (2024). Comparison of Antioxidants in Red Ginger Powder Preparations with the Addition of Sucrose and Red Ginger Powder Preparations Without the Addition of Sucrose. Jurnal.Poltekkespalu.Ac.Id, 17(4), 1436–1441. https://jurnal.poltekkespalu.ac.id/index.php/JIK/article/view/3554

Dwita, L. P., Maifitrianti, M., & Viviandhari, D. (2019). Pembuatan Sirup Jahe Merah dan Pemafaatannya dalam Kesehatan. Jurnal SOLMA, 8(1), 111. https://doi.org/10.29405/solma.v8i1.3080

El Halawany, A. M., EL Sayed, N. S., Abdallah, H. M., & El Dine, R. S. (2023). Retraction Note: Protective effects of gingerol on streptozotocin-induced sporadic Alzheimer’s disease: emphasis on inhibition of β-amyloid, COX-2, alpha-, beta - secretases and APH1a (Scientific Reports, (2017), 7, 1, (2902), 10.1038/s41598-017-02961-0). Scientific Reports, 13(1), 41598. https://doi.org/10.1038/s41598-023-36652-w

Ezzat, S. M., Ezzat, M. I., Okba, M. M., Menze, E. T., & Abdel-Naim, A. B. (2018). The hidden mechanism beyond ginger (Zingiber officinale Rosc.) potent in vivo and in vitro anti-inflammatory activity. Journal of Ethnopharmacology, 214, 113–123. https://doi.org/10.1016/j.jep.2017.12.019

Febyan, F., Wijaya, S. H., Tannika, A., & Hudyono, J. (2020). Peranan Sitokin pada Keadaan Stres sebagai Pencetus Depresi. Jurnal Penyakit Dalam Indonesia, 6(4), 210. https://doi.org/10.7454/jpdi.v6i4.285

Ghasemzadeh, A., Jaafar, H. Z. E., & Rahmat, A. (2016). Variation of the phytochemical constituents and antioxidant activities of Zingiber officinale var. rubrum Theilade associated with different drying methods and polyphenol oxidase activity. Molecules, 21(6). https://doi.org/10.3390/molecules21060780

Guo, M., Mi, J., Jiang, Q. M., Xu, J. M., Tang, Y. Y., Tian, G., & Wang, B. (2014). Metformin may produce antidepressant effects through improvement of cognitive function among depressed patients with diabetes mellitus. Clinical and Experimental Pharmacology and Physiology, 41(9), 650–656. https://doi.org/10.1111/1440-1681.12265

Holland, I., Deville, N. V., Browning, M. H. E. M., Buehler, R. M., Hart, J. E., Aaron Hipp, J., Mitchell, R., Rakow, D. A., Schiff, J. E., White, M. P., Yin, J., & James, P. (2021). Measuring nature contact: A narrative review. International Journal of Environmental Research and Public Health, 18(8), 1–15. https://doi.org/10.3390/ijerph18084092

Hsu, T. M., Konanur, V. R., Taing, L., Usui, R., Kayser, B. D., Goran, M. I., & Kanoski, S. E. (2015). Effects of sucrose and high fructose corn syrup consumption on spatial memory function and hippocampal neuroinflammation in adolescent rats. Hippocampus, 25(2), 227–239. https://doi.org/10.1002/hipo.22368

Jacques, A., Chaaya, N., Beecher, K., Ali, S. A., Belmer, A., & Bartlett, S. (2019). The impact of sugar consumption on stress driven, emotional and addictive behaviors. Neuroscience and Biobehavioral Reviews, 103(March), 178–199. https://doi.org/10.1016/j.neubiorev.2019.05.021

Kartika, W., Sulistyowati, E., Herlyanti, K., Mighfar Syukur, Nugraheni, B., & Suryaning Prahasiwi, M. (2023). Pembuatan Minuman Herbal Instan dengan Bahan Jahe, Sereh, Kelor (Jaseke) untuk Stamina Tubuh. Jurnal DiMas, 5(2), 58–63. https://doi.org/10.53359/dimas.v5i2.68

Kim, J. E., Shrestha, A. C., Kim, H. S., Ham, H. N., Kim, J. H., Kim, Y. J., Noh, Y. J., Kim, S. J., Kim, D. K., Jo, H. K., Kim, D. S., Moon, K. H., Lee, J. H., Jeong, K. O., & Leem, J. Y. (2019). WS-5 Extract of Curcuma longa, Chaenomeles sinensis, and Zingiber officinale Contains Anti-AChE Compounds and Improves β -Amyloid-Induced Memory Impairment in Mice. Evidence-Based Complementary and Alternative Medicine, 2019. https://doi.org/10.1155/2019/5160293

Kim, S., Shou, J., Abera, S., & Ziff, E. B. (2018). Sucrose withdrawal induces depression and anxiety-like behavior by Kir2.1 upregulation in the nucleus accumbens. Neuropharmacology, 130, 10–17. https://doi.org/10.1016/j.neuropharm.2017.11.041

Kiyama, R. (2020). Nutritional implications of ginger: chemistry, biological activities and signaling pathways. Journal of Nutritional Biochemistry, 86, 108486. https://doi.org/10.1016/j.jnutbio.2020.108486

Koch, W., Kukula-Koch, W., Dziedzic, M., Glowniak, K., & Asakawa, Y. (2016). Influence of thermal processing and in vitro digestion on the antioxidant potential of ginger and ginger containing products. Natural Product Communications, 11(8), 1153–1156. https://doi.org/10.1177/1934578x1601100830

Lee, S. H., Zhao, L., Park, S., Moore, L. V., Hamner, H. C., Galuska, D. A., & Blanck, H. M. (2023). High Added Sugars Intake among US Adults: Characteristics, Eating Occasions, and Top Sources, 2015–2018. Nutrients, 15(2), 2015–2018. https://doi.org/10.3390/nu15020265

Lemos, C., Rial, D., Gonçalves, F. Q., Pires, J., Silva, H. B., Matheus, F. C., da Silva, A. C., Marques, J. M., Rodrigues, R. J., Jarak, I., Prediger, R. D., Reis, F., Carvalho, R. A., Pereira, F. C., & Cunha, R. A. (2016). High sucrose consumption induces memory impairment in rats associated with electrophysiological modifications but not with metabolic changes in the hippocampus. Neuroscience, 315, 196–205. https://doi.org/10.1016/j.neuroscience.2015.12.018

Luettig, J., Rosenthal, R., Lee, I. F. M., Krug, S. M., & Schulzke, J. D. (2016). The ginger component 6-shogaol prevents TNF-α-induced barrier loss via inhibition of PI3K/Akt and NF-κB signaling. Molecular Nutrition and Food Research, 60(12), 2576–2586. https://doi.org/10.1002/mnfr.201600274

Mahdy, K. A., & Farrag, A. R. H. (2016). Protective Effect of Ginger (Zingiber officinale) on Alzheimer’s disease Induced in Rats. February. https://www.researchgate.net/profile/Abdel-RazikFarrag/publication/283910018_Protective_Effect_of_Ginger_Zingiber_officinale_on_Alzheimer's_disease_Induced_in_Rats/links/56bc5d4908ae0a407db15c71/Protective-Effect-of-Ginger-Zingiber-officinale-on-Alzheimers-disease-Induced-in-Rats.pdf

Mantantzis, K., Schlaghecken, F., Sünram-Lea, S. I., & Maylor, E. A. (2019). Sugar rush or sugar crash? A meta-analysis of carbohydrate effects on mood. Neuroscience and Biobehavioral Reviews, 101(March), 45–67. https://doi.org/10.1016/j.neubiorev.2019.03.016

Mao, Q. Q., Xu, X. Y., Cao, S. Y., Gan, R. Y., Corke, H., Beta, T., & Li, H. Bin. (2019). Bioactive compounds and bioactivities of ginger (zingiber officinale roscoe). Foods, 8(6), 1–21. https://doi.org/10.3390/foods8060185

Mustafa, I., & Chin, N. L. (2023). Antioxidant Properties of Dried Ginger (Zingiber officinale Roscoe) var. Bentong. Foods, 12(1), 1–18. https://doi.org/10.3390/foods12010178

Orr, M. E., Salinas, A., Buffenstein, R., & Oddo, S. (2014). Mammalian target of rapamycin hyperactivity mediates the detrimental effects of a high sucrose diet on Alzheimer’s disease pathology. Neurobiology of Aging, 35(6), 1233–1242. https://doi.org/10.1016/j.neurobiolaging.2013.12.006

Prasad, K., & Dhar, I. (2014). Oxidative stress as a mechanism of added sugar-induced cardiovascular disease. International Journal of Angiology, 23(4), 217–226. https://doi.org/10.1055/s-0034-1387169

Rachmad Saputra, Bela Safitri Wahyudi, Fajar Aulia Rahman, Muhammad Ammar Huseini, Harry Firmansyah, Arum Sekar Priyati, Hanifa Febriani, Nurul Fadhila Ramadhona, Putri Khairani, Rifa Shovia, & Riska JH Jundiah. (2022). PENGOLAHAN RIMPANG JAHE (Zingiber officinale Rosc.) SEBAGAI MINUMAN HERBAL PADA ERA NEW NORMAL DI DESA GUNUNG MULYA KABUPATEN KAMPAR. PAKDEMAS : Jurnal Pengabdian Kepada Masyarakat, 2(1), 147–152. https://doi.org/10.58222/pakdemas.v2i1.78

Rahman, I. R., Hairunnisa, H., Kurnianto, E., Kartikasari, D., & Hamdi, A. (2023). Formulasi Hard Candy Dengan Kombinasi Jahe Merah, Lemon Dan Sereh. Jurnal Ilmiah Pharmacy, 10(2), 107–116. https://doi.org/10.52161/jiphar.v10i2.500

Ratnaningsih, A. T., Insusanty, E., & Ervayendri. (2021). Pelatihan Pembuatan Minuman Kesehatan Jahe Merah Instan BagiTim Penggerak Pemberdayaan Dan Kesejahteraan KeluargaKelurahan Limbungan Kota Pekanbaru. Prosiding Seminar Nasional Pengabdian Kepada Masyarakat, 1(2), 33–38. https://journal.unilak.ac.id/index.php/SNPKM/article/view/11406

Rifkowaty, E. E., & Martanto. (2016). MINUMAN FUNGSIONAL SERBUK INSTAN JAHE (Zingiber officinalerosc) DENGAN VARIASI PENAMBAHAN EKSTRAK BAWANG MEKAH(Eleutherine Americana Merr) SEBAGAI PEWARNA ALAMI. Jurnal Teknik Pertanian Lampung, 4(4), 315–324.https://r.search.yahoo.com/_ylt=Awr1UZkvbKNnegIAWO7LQwx.;_ylu=Y29sbwNzZzMEcG9zAzEEdnRpZAMEc2VjA3Ny/RV=2/RE=1739972911/RO=10/RU=https%3a%2f%2fmedia.neliti.com%2fmedia%2fpublications%2f134382-ID-none.pdf/RK=2/RS=qsCltIzcN8L1J4p0gDKBzngd9Ak-

Roslinda, E., Widiastuti, T., Khumsyah, A. A. N., Nurfatimah, U., Karlindasari, W., & Syasabila, D. A. (2022). Pelatihan Pembuatan Sirup Jahe Dalam Usaha Menciptakan Nilai Tambah Tanaman Jahe Masyarakat. JMM (Jurnal Masyarakat Mandiri), 6(4), 2674. https://doi.org/10.31764/jmm.v6i4.8977

Rosyanti, L., Usman, R. D., Hadi, I., & Syahrianti, S. (2017). Kajian Teoritis Hubungan antara Depresi dengan Sistem Neuroimun. Health Information : Jurnal Penelitian, 9(2), 78–97. https://doi.org/10.36990/hijp.v9i2.104

Sanjay, S. S., & Shukla, A. K. (2021). Potential Therapeutic Applications of Nano-antioxidants. In Potential Therapeutic Applications of Nano-antioxidants. https://doi.org/10.1007/978-981-16-1143-8

Santos, C. J., Ferreira, A. V. M., Oliveira, A. L., Oliveira, M. C., Gomes, J. S., & Aguiar, D. C. (2018). Carbohydrate-enriched diet predispose to anxiety and depression-like behavior after stress in mice. Nutritional Neuroscience, 21(1), 33–39. https://doi.org/10.1080/1028415X.2016.1213529

Saras, T. (2023). The Wonders of Ginger: Unveiling the Health Benefits and Culinary Magic. Tiram Media.https://books.google.co.id/books?hl=en&lr=&id=MtPQEAAAQBAJ&oi=fnd&pg=PA1&dq=Saras,+T.+(2023).+The+Wonders+of+Ginger:+Unveiling+the+Health+Benefits+and+Culinary+Magic.+Tiram+Media.&ots=wT473yenRj&sig=At6aJJ1leFwzm2obHtI6lG6ADn8&redir_esc=y#v=onepage&q=Saras%2C%20T.%20(2023).%20The%20Wonders%20of%20Ginger%3A%20Unveiling%20the%20Health%20Benefits%20and%20Culinary%20Magic.%20Tiram%20Media.&f=false

Shaukat, M. N., Nazir, A., & Fallico, B. (2023). Ginger Bioactives: A Comprehensive Review of Health Benefits and Potential Food Applications. Antioxidants, 12(11), 1–26. https://doi.org/10.3390/antiox12112015

Siddaway, A. P., Wood, A. M., & Hedges, L. V. (2019). How to Do a Systematic Review: A Best Practice Guide for Conducting and Reporting Narrative Reviews, Meta-Analyses, and Meta-Syntheses. Annual Review of Psychology, 70, 747–770. https://doi.org/10.1146/annurev-psych-010418-102803

Singh, S., & Kumar, K. (2020). Review of literature of lean construction and lean tools using systematic literature review technique (2008–2018). Ain Shams Engineering Journal, 11(2), 465–471. https://doi.org/10.1016/j.asej.2019.08.012

Sueishi, Y., Masamoto, H., & Kotake, Y. (2019). Heat treatments of ginger root modify but not diminish its antioxidant activity as measured with multiple free radical scavenging (MULTIS) method. Journal of Clinical Biochemistry and Nutrition, 64(2), 143–147. https://doi.org/10.3164/jcbn.18-41

Sultana, A., Rahman, K., Heyat, M. B. Bin, Sumbul, Akhtar, F., & Muaad, A. Y. (2022). Role of Inflammation, Oxidative Stress, and Mitochondrial Changes in Premenstrual Psychosomatic Behavioral Symptoms with Anti-Inflammatory, Antioxidant Herbs, and Nutritional Supplements. Oxidative Medicine and Cellular Longevity, 2022. https://doi.org/10.1155/2022/3599246

Supriyanto, S., Mojiono, M., & Dewi, M. W. P. (2023). Efek Penambahan Ekstrak Jahe (Zingiber officinale Rosc.) Serta Rasio Glukosa dan Fruktosa Pada Sucrose-Free Hard Candy. Rekayasa, 16(2), 122–131. https://doi.org/10.21107/rekayasa.v16i2.20158

Sutantio, E. H., & Nugroho, I. I. (2020). Inflamation As a Depression-Causing Factor in Chronic Kidney Disease Patients. Journal of Psychiatry Psychology and Behavioral Research, 1(1), 15–19. https://jppbr.ub.ac.id/index.php/jppbr/article/view/4

Tambunan, I. J., Ginting, E., Yulia, R., & Ramadhan, A. (2022). Sosialisasi Pembuatan Minuman Wedang Jahe Instan Untuk Penguat Imunitas Mencegah Covid-19 Di Sekolah Menengah Kejuruan (Smk) Farmasi Apipsu Medan. Jurnal Pengabdian Masyarakat Tjut Nyak Dhien, 1(2), 76–82. https://doi.org/10.36490/jpmtnd.v1i2.312

The Ginger People. (2021). GIN GINS® Ginger Candy. The Ginger People. https://gingerpeople.com/products/gin-gins-super-strength-ginger-candy/

Tizabi, Y., Hurley, L. L., Qualls, Z., & Akinfiresoye, L. (2014). Relevance of the anti-inflammatory properties of curcumin in neurodegenerative diseases and depression. Molecules, 19(12), 20864–20879. https://doi.org/10.3390/molecules191220864

Tung, B. T., Thu, D. K., Thu, N. T. K., & Hai, N. T. (2017). Antioxidant and acetylcholinesterase inhibitory activities of ginger root (Zingiber officinale Roscoe) extract. Journal of Complementary and Integrative Medicine, 14(4). https://doi.org/10.1515/jcim-2016-0116

Ueno, N., Hasebe, T., Kaneko, A., Yamamoto, M., Fujiya, M., Kohgo, Y., Kono, T., Wang, C. Z., Yuan, C. S., Bissonnette, M., Chang, E. B., & Musch, M. W. (2014). TU-100 (Daikenchuto) and ginger ameliorate anti-CD3 antibody induced T cell-mediated murine enteritis: Microbe-independent effects involving Akt and NF-kB suppression. PLoS ONE, 9(5), 1–9. https://doi.org/10.1371/journal.pone.0097456

Wiendarlina, I. Y., & Sukaesih, R. (2019). PERBANDINGAN AKTIVITAS ANTIOKSIDAN JAHE EMPRIT (Zingiber officinale var Amarum) DAN JAHE MERAH (Zingiber officinale var Rubrum) DALAM SEDIAAN CAIR BERBASIS BAWANG PUTIH DAN KORELASINYA DENGAN KADAR FENOL DAN VITAMIN C. Jurnal Fitofarmaka Indonesia, 6(1), 315–324. https://doi.org/10.33096/jffi.v6i1.464

Xu, T. J., & Reichelt, A. C. (2018). Sucrose or sucrose and caffeine differentially impact memory and anxiety-like behaviours, and alter hippocampal parvalbumin and doublecortin. Neuropharmacology, 137, 24–32. https://doi.org/10.1016/j.neuropharm.2018.04.012

Zhang, F., Zhang, J. G., Yang, W., Xu, P., Xiao, Y. L., & Zhang, H. T. (2018). 6-Gingerol attenuates LPS-induced neuroinflammation and cognitive impairment partially via suppressing astrocyte overactivation. Biomedicine and Pharmacotherapy, 107(April), 1523–1529. https://doi.org/10.1016/j.biopha.2018.08.136

Zhang, S., Kou, X., Zhao, H., Mak, K. K., Balijepalli, M. K., & Pichika, M. R. (2022). Zingiber officinale var. rubrum: Red Ginger’s Medicinal Uses. Molecules, 27(3). https://doi.org/10.3390/molecules27030775




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